RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
Nox4
RNA ID
RNA Type
mRNA
Alteration Pattern
histone deacetylation
Species
rattus norvegicus
Detection Methods
Engineered CRISPR-Cas9 and DNA constructs; qRT-PCR; Promoter activity assays etc.
Target
NA
Pathway
NA
PubMed ID
Title
Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension
Year
2016
Function
"HDAC inhibitors block the binding of RNA polymerase II and the histone acetyltransferase p300 to the Nox2, Nox4 and Nox5 promoter regions and decrease histones activation marks (H3K4me3 and H3K9ac) at these promoter sites. In a monocrotaline (MCT) rat model of PAH, multiple HDAC isoforms are upregulated in isolated pulmonary arteries, and HDAC inhibitors attenuate Nox expression in isolated pulmonary arteries and reduce indices of PAH. In conclusion, HDAC inhibitors potently suppress Nox gene expression both in vitro and in vivo via epigenetically regulating chromatin accessibility."